| Hardware and OS | Vivo V21 Pro 256GB 8GB RAM | |
| Operating system | Android v10 (Q) | |
| Processor | Octa-core (1x2.4 GHz Kryo 475 Prime & 1x2.2 GHz Kryo 475 Gold & 6x1.8 GHz Kryo 475 Silver) | |
| Chipset | Qualcomm Snapdragon 765G - 7 nm | |
| Internal Storage | 256 GB | |
| GPU | Adreno 620 | |
| RAM | 8 GB | |
| Camera | Vivo V21 Pro 256GB 8GB RAM | other phones |
| Main camera | 48 MP 13 MP 8 MP 2 MP | |
| Autofocus | Yes | |
| Camera features | Digital Zoom, Auto Flash, Face detection, Touch to focus | |
| Flash | Yes, LED Flash | |
| Front camera | 32 MP | |
| Front camera resolution | 32 MP, f/2.0, (wide) | |
| Video recording | Yes | |
| Connectivity | Vivo V21 Pro 256GB 8GB RAM | other phones |
| Bluetooth | Yes, v5.0 | |
| SIM size | SIM1: Nano, SIM2: Nano | |
| Dual SIM | Dual SIM, GSM GSM | |
| GPS | Yes, with A-GPS, Glonass | |
| Network support | 4G , 3G, 2G | |
| USB connectivity | Mass storage device, USB charging | |
| WI-FI | Yes, Wi-Fi 802.11, b/g/n | |
| Multimedia | Vivo V21 Pro 256GB 8GB RAM | other phones |
| Audio jack | 3.5 MM | |
| Loudspeaker | Yes | |
| Battery | Vivo V21 Pro 256GB 8GB RAM | other phones |
| Capacity | 4350 mAh | |
| Type | Li-Polymer | |
| User replaceable | No | |
| Design | Vivo V21 Pro 256GB 8GB RAM | other phones |
| Colors | Black, Blue | |
| Height | 162.1 mm | |
| Width | 75 mm | |
| Thickness | 8.9 mm | |
| Weight | 200 grams | |
| Features | Vivo V21 Pro 256GB 8GB RAM | other phones |
| Fingerprint sensor position | On-Screen | |
| Fingerprint sensor | Yes | |
| Other sensors | Accelerometer, Gyro, Proximity, Compass | |