| Hardware and OS | Honor 80 SE | |
| Operating system | Android 12, Magic UI 7 | |
| Processor | Octa-core (2x2.4 GHz Cortex-A78 & 6x2.0 GHz Cortex-A55) | |
| Chipset | MediaTek MT6877 Dimensity 900 (6 nm) | |
| GPU | Mali-G68 MC4 | |
| Internal memory | 256GB 8GB RAM, 256GB 12GB RAM | |
| External memory | No | |
| Display | Honor 80 SE | other phones |
| Type | OLED, 1B colors, 120Hz | |
| Size | 6.67 inches, 107.9 cm2(~91.2% screen-to-body ratio) | |
| Resolution | 1080 x 2400 pixels | |
| Connectivity | Honor 80 SE | other phones |
| 2G Network | GSM 850 / 900 / 1800 / 1900 - SIM 1 & SIM 2 | |
| 3G Network | HSDPA 800 / 850 / 900 / 1700(AWS) / 1900 / 2100 | |
| 4G Network | LTE | |
| 5G Network | SA/NSA | |
| WLAN | Wi-Fi 802.11 a/b/g/n/ac, dual-band, Wi-Fi Direct | |
| Bluetooth | 5.1, A2DP, LE | |
| NFC | No | |
| USB | USB Type-C 2.0, USB On-The-Go | |
| CDMA | CDMA 800 | |
| Speed | HSPA, LTE-A, 5G | |
| Technology | GSM / CDMA / HSPA / CDMA2000 / LTE / 5G | |
| Main Camera | Honor 80 SE | other phones |
| Camera | 64 MP, f/1.8, (wide), PDAF 5 MP, f/2.2, (ultrawide) 2 MP, f/2.4, (macro) | |
| Features | LED flash, HDR, panorama | |
| Video | 4K@30fps, 1080p@30/60fps | |
| Selfie camera | Honor 80 SE | other phones |
| Camera | 32 MP, f/2.4, (wide) | |
| Features | HDR | |
| Video | 1080p@30fps | |
| Multimedia | Honor 80 SE | other phones |
| Multimedia | 24-bit/192kHz audio | |
| 3.5 mm Jack | No | |
| Loudspeaker | Yes | |
| Battery | Honor 80 SE | other phones |
| Type | Li-Po 4600 mAh, non-removable | |
| Charging | 66W wired, 3-80% in 30 min (advertised) | |
| Design | Honor 80 SE | other phones |
| SIM | Dual SIM (Nano-SIM, dual stand-by) | |
| Weight | 175 g (6.17 oz) | |
| Dimensions | 161.3 x 73.4 x 7.7 mm (6.35 x 2.89 x 0.30 in) | |
| Colors | Black, Blue, Pink, Crystal Blue | |
| Features | Honor 80 SE | other phones |
| Sensors | Fingerprint (under display, optical), accelerometer, proximity, compass | |